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KMID : 1022820180090010001
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Journal of Multiple Sclerosis and Neuroimmunology
2018 Volume.9 No. 1 p.1 ~ p.6
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Myelin Oligodendrocyte Glycoprotein Immunoglobulin-G Associated Central Nervous System Inflammatory Disorder
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Ryu Seong-Geun
Park Min-Su
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Abstract
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Autoantibody against myelin oligodendrocyte glycoprotein (MOG) has been recently recognized as a new inflammatory disease entity distinct from multiple sclerosis (MS) and aquaporin-4 (AQP4) antibody positive neuromyelitis optica spectrum disorder (NMOSD). MOG autoantibody may cause oligodendrocyte damage and myelin dysfunction without astrocytopathy. MOG-immunoglobulin G (IgG) is detected in 4-10% of central nervous system (CNS) inflammatory demyelinating disorders that include MS, NMOSD, acute disseminated encephalomyelitis (ADEM), idiopathic optic neuritis and idiopathic acute transverse myelitis. MOG-IgG disease affects female slightly more than male. The most common clinical phenotype is optic neuritis followed by myelitis, brainstem symptoms, ADEM like presentation and multifocal involvement. About 50-80% of MOG-IgG disease have relapsing disease course and relapsing optic neuritis is the most common clinical syndrome. Acute treatment and long term maintenance therapy are needed in MOG-IgG disease. Prognosis in MOG-IgG disease has more favorable outcome than AQP4 antibody positive NMOSD.
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KEYWORD
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Myelin oligodendrocyte glycoprotein, Neuromyelitis optica spectrum disorder, Aquaporin 4
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